Making artificial genetic changes that are inheritable, that is changes that will be passed on to their offspring. Also called Germline modification, and generally regarded as very unwise by most scientists, given the limitations of our current knowledge. Fifteen human children have been so modified using a technique called ooplasmic transfer. This involves taking some of the contents from a donor cell and injecting it into the egg cell of another woman

Source:
http://news.bbc.co.uk/hi/english/sci/tech/newsid_1312000/1312708.stm