Student Doctor Eugene Eskow sat at the table in the patient lounge, his H & P unfinished. Morning report was less than 6 hours away, there was work left to be done, and I pushed him a bit to finish the write-up. We took call together when we could; we each trusted the other.
Mike, I need to understand the process; I want to get it right.
I rolled my eyes--Gene, for fuck's sake, it's after 2, we have 3 IV's to start, and the sun's coming up soon. Just put down something, a working diagnosis.
He just looked up at me, then back to his paper. He was still getting used to my impatient language, I was still getting used to his methodical ways. The patient was elderly, with multiple problems, multiple organs trying to fail. We had too much work to do, too little sleep, too little time.
He was from a small town, and, as he loved to remind me, had small town ways. He wanted to become a family doctor, not something most of us would dream of during the glamor days of medical school, when anything was still possible. I'm a hick....His smile made him look like a young Bob Hope.
I left him there, muttering obscenities, but I knew he would not budge. Not until he figured out what made his patient sick.
Lyme disease, despite all the rhetoric, fits the disease model well. We know the
organism, we know the
vector, we know the
treatment.
The disease became known just as the internet became popular. As is true for any disease, we knew very little about it initially, and diagnosis was difficult in many cases. We had no reliable serologic markers. While the disease has a characteristic rash, not everyone who gets the disease gets the rash. Even more confusing, not everyone who gets infected becomes ill.
Many of the symptoms of Lyme disease are nonspecific--they are symptoms common to a litany of illnesses. Fever, joint pain, headaches, fatigue, memory loss. The neurologic symptoms are particularly troubling, and can be subtle.
The organism causing Lyme disease is sensitive to a variety of antibiotics. Despite this, some people who receive a course of antbiotics continue to be ill. The physician tests the patient's blood, pronounces the Lyme disease cured, but the patient has not been healed. Some doctors trust their lab results more than their patients.
Many patients with chronic symptoms understandably wanted a longer course of treatment; many doctors were happy to oblige. The insurance companies, however, citing lack of evidence of Lyme's disease in many chronically ill patients, refused (again understandably) to cover the cost of treatments.
Some patients see a conspiracy, as noded above. Some doctors see whiney patients. Dr. Eskow saw something else.
Dr. Eskow ended up in family practice in Flemington, New Jersey. He survived medical school with his small town ways intact. He trusts his patients.
Dr. Eskow is a very nice person who listens attentively to his patients concerns.
Jeff, from Virtual Ratings
Lyme Disease is rampant where he practices. He knows the disease as well as anyone in primary care. He also knows his patients. Some of his patients clearly had Lyme disease. The tests said they were cured, but they still had symptoms. Dr. Eskow had an idea.
Bartonella henselae is a bacteria associated with cats, not ticks. Cat Scratch Fever is a disease not usually associated with neurologic symptoms. Still, Dr. Eskow was aware of reports of B. henselae in the same species of mice that carry Lyme's. A Dutch study had already shown B. henselae in European deer ticks.
The same relentless search for answers that caused Dr. Eskow grief as a student provided relief to his patients.
Four patients who had been infected with Lyme Disease yet continued with neurologic symptoms were tested for B. henselae. None of these patients had had known exposure to cats. All 4 tested positive in the blood and spinal fluid for antibodies specific to this bacteria. Even more importantly, all 4 got better when subsequently treated for B. henselae.
I feel this is at least one reason why people can get treated for Lyme and not get better. This is a completely different bacteria that standard Lyme antibiotics will not eradicate.Eugene Eskow, M.D.
Please note: Dr. Eskow said that this may be just one reason. If there are other reasons for folks living in his
neck of the woods, I trust Gene will find it.
Mike, I need to understand....
Sources:
Personal observations--classmates at the New Jersey Medical School
Eugene Eskow, MD; Raja-Vemkitesh S. Rao, PhD; Eli Mordechai, PhD, "Concurrent Infection of the Central Nervous System by Borrelia burgdorferi and Bartonella henselae," Arch Neurol. 2001;58:1357-1363. see http://archneur.ama-assn.org/cgi/content/abstract/58/9/1357
Bull's-eye, Targeting Lyme Disease, Excerpts from Vol. 11.5, October, 2001, http://www.geocities.com/ldbullseye/bullseye.html.
Jeff, in Virtual Ratings Review for Doctors, http://www.virtualratings.com/items.asp?item=13792.