If women are supposed to be less rational and more emotional at the beginning of our menstrual cycle when the female hormone is at its lowest level, then why isn't it logical to say that, in those few days, women behave the most like the way men behave all month long?
Gloria Steinem
I've always felt sorry for boys, biology-wise. They definitely got the bum end of it in terms of interesting hormonal reflexes. The female menstrual cycle has been constantly revised in my education since I was 8; year after year we'd return to it in Biology and learn a little bit more about its intricacies. Girls, of course, had the upper hand; we get the joy of having to experience this knowledge in a practical setting once a month. Boys just sat there, clueless. And excluded... I didn't get taught about the process of spermatogenesis till I got to my first year of university. If you were to ask the average girl what she knew about her reproductive affairs, she could give you the basic ins and outs of it. Ask your average boy (and I have) what their gonads do, and the best they can (usually) come up with is some sexual innuendo along the lines of "rock your world, baby!" That quote there is courtesy of a long, long ago ex. I tend to pick the cute-but-dumb ones.
So, to redress a balance, in this write-up of the female menstrual cycle, I will drop in occasional pearls about the male gonads, which are a lot more interesting than the secondary school educational system would have you believe.
Menarche
'Gonads' are the primary reproductive organs in the body; ovaries for girls and testes for boys. Whilst boy's testes produce sperm continually from puberty until death, girls are born with their ovaries already containing all the eggs that they'll ever use in their lifetime. Which is quite a whacky concept if you think about it; when your mum was incubating in your grandmother's womb, half of you was in there as well. How cool is that?
As a girl grows, her ovaries gradually mature. They secrete minute amounts of oestrogen all this time to inhibit the release of gonadotropin-releasing hormone (GnRH), which is the hormone that causes the release of other hormones that stimulate ovulation. This state of affairs continues until a girl is around 8 years of age; from this point forward, GnRH levels will gradually start to rise, triggering the development of secondary sexual characteristics. About three years after this, a girl will experience menarche: her first menstrual period. Of course, this isn't set in stone; some girls will have their first period aged 9, some will have it aged 17. If her first period occurs either before or after this age range, then it indicates that there may be something medically wrong that needs further investigation.
The ovarian cycle
The ovarian cycle is different from the menstrual cycle; the ovarian cycle describes the hormonal development of the oocyte (egg cell) and the menstrual cycle describes the development of the lining of the uterus. However it is beneficial to consider one before looking at the other. The ovarian cycle is only complicated if you think of it being complicated. That's what I tell myself come exam time anyway. It's regulated by five hormones: GnRH, luteinizing hormone (LH), follicle-stimulating hormone (FSH), oestrogen and progesterone. Each cycle takes approximately 28 days to complete; the normal range is considered to between 21-35 days. It is a commonly held misconception that a woman's period will coincide with the phases of the moon; not so. If it were that predictable, life would be a lot easier. Not all women are as regular as clockwork; one cycle may take 25 days while the next takes 32. Of course, some women are as regular as clockwork and are guaranteed to come on at 7am every fourth Sunday.
Fun Fact #1: men use exactly the same hormones in the production of sperm, except for a substitution of testosterone for oestrogen and progesterone. It takes men approximately 16 days to work through their hormone cycle, which means they have nearly twice as many 'PMT' episodes per year than women. Stick that in your pipe and smoke it.
At birth, the ovary is packed full of potential egg cells (around 2 million), only a fraction of which will ever see the light of day; a lot die off before puberty, with only 400,000 primary oocytes remaining at menarche, and only about 500 ever completing the ovarian cycle. The number of viable ova continue to diminish as a woman ages, by 30yrs there's only 100,000 left, and by the age of 50, it's down to just 3 (Marieb, 2001). At the beginning of the ovarian cycle, the primary oocytes are stimulated by GnRH, FSH and LH to begin developing from a primary oocyte into a primary follicle, which begin secreting oestrogen. The follicle then further develops into becoming a granulosa cell, and then into a theca folliculi. By this point it's secreting enough oestrogen to initiate a negative feedback cycle on LH and FSH, inhibiting their production. The folliculi continues to develop, and begins to bulge out of the side of the ovary. It is around this time that meiosis I occurs, which results in the formation of a secondary oocyte, and a polar body (the 'junk' potion of meiosis I).
Fun Fact #2: In males, meiosis produces four gamete cells (sperm), in contrast to female meiosis, which only produces one gamete (egg).
By now, the folliculi is producing so much oestrogen that a positive feedback cycle is initiated for LH and FSH; remember, a little oestrogen has a negative feedback, a lot of oestrogen has a positive feedback. Craziness. This occurs around day 14, and this sudden surge of LH, FSH and oestrogen causes the folliculi to burst, releasing the secondary oocyte into the fallopian tubes. Some women experience pain when the folliculi bursts; in German, this pain is call mittelschmerz, or "middle pain", and is caused by the stretching of the ovarian wall during ovulation. Only 1-2% of ovulations produce more than one egg (which, if both are fertilised, will produce fraternal twins). Secondary meiosis (meiosis II) will only occur if a sperm fertilises the secondary oocyte; the sperm only have a 12-24hr window to reach their target, so it's quite a tight schedule. The more I discover about the process of procreation, the more shocked I am that the human race still exists.
Fun Fact #3: Women usually produce only one gamete every ~28 days. Men produce 400million a day. That's 4,700 a second. I often present this fact to a member of the opposite sex, and this is the point where I start counting: 4,700 mississippi; 9,400 mississippi; 14,100 mississippi; 18,800 mississippi; 23,500 mississippi... Poor boys. You must feel permanently drained by all that genetic division.
The ruptured folliculi left in the ovary is now stimulated by the LH surge to collapse down and form the corpus luteum, a "yellow body" in the ovary that secretes oestrogen and progesterone to maintain the lining of the uterus in preparation for implantation of an embryo. FH and LH secretion is once again inhibited by the lower levels of oestrogen until the end of the cycle, when the whole merry dance starts again. If implantation does not occur, then the corpus luteum dies, causing the lining of the uterus to shed, which brings us very nicely around to...
The menstrual cycle
The menstrual cycle describes the monthly preparation of the uterus for implantation of a fertilised ovum. The uterine endometrium in its normal state is not, in itself, all that hospitable to receiving an egg, so it has to develop a lining that is. Like the primary follicles, the uterine endometrium responds to changing levels of hormones, and so is coordinated with the phases of the ovarian cycle. Assuming a 28-day menstrual cycle, it goes something like this:
Days 1-5 – This is the menstrual phase; the portion of the cycle where the lining of the uterus sloughs off, resulting in a menstrual period, or menses, where a woman bleeds for 3-5 days. By day 5, the growing primary follicle is starting to produce oestrogen.
Days 6-14 – This is the proliferative phase; the portion of the cycle where the uterine endometrium starts to rebuild itself, stimulated by the rising levels of oestrogen being released by the primary follicle. The basal layer of the endometrium generates a glandular layer that slowly thickens. This new layer is supplied by spiral arteries, which gradually increase in number. They are literally shaped like spirals, which allows them to grow with the new lining as it thickens. By day 14, the lining is thick and velvety, and very well vascularised; the perfect place to grow an egg. The steadily growing levels of oestrogen have stimulated the receptor cells of the endometrial lining to produce receptors for progesterone. When ovulation occurs on day 14, the corpus luteum develops and starts to produce large amounts of progesterone and oestrogen, preparing the lining for implantation.
Days 15-28 – This is the secretory phase; this is where the endometrium prepares itself for the implantation of an embryo. The progesterone acts on the endometrial lining, causing further proliferation of the spiral arteries, and for a secretory mucosa to develop that releases nutritious glycoproteins that'll keep the embryo fed until full implantation has occurred. If fertilisation has failed to occur, the corpus luteum will slowly begin to die off, causing a drop in the release of progesterone. Since progesterone is the hormone that maintains the endometrial lining, as the progesterone decreases, the lining will start to degrade and self-digest. On day 1, it will start to slough off, and the cycle starts again. However, if fertilisation does occur, the embryo will release human chorionic gonadotropin (hCG), which maintains the corpus luteum, thus also maintaining the endometrial lining.
The menstrual cycle is exactly that; a cycle. This will keep on repeating itself until either pregnancy, where it takes a break for nine months; or until the ovaries run out of eggs. This point is called menopause, and will usually occur around the ages of 45-55.
Menstrual abnormalities
There are many, many different problems that can affect a woman's menstrual cycle; this is why gynaecologists earn so much. It's pointless to go through each one (not least because there's so many of the damn things), but a list of medical terminologies that are used to describe abnormal menstrual cycles is:
And that's why women have
gynaecologists and men only have
urologists.
Reference
- Marieb E N, 2001,"Human Anatomy and Physiology", 5th edition, Addison Wesley Longman